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Look at alternant therapies that are not average CYP3A inducers during treatment with mitapivat. If struggling to stay away from coadministration, observe Hb and titrate further than 50 mg BID, if essential, but tend not to exceed mitapivat dose of 100 mg BID. .pentobarbital will lessen the level or result of bexarotene by influencing hepatic/intes